Pancreatic Adenocarcinoma Up-regulated Factor
PAUF
- Secreted protein involved in pancreatic cancer progression and metastasis
- Novel target for the treatment and diagnosis of pancreatic cancer.
TME modulator
![자산 1422@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-1422@3x-8.png)
- The tumor microenvironment (TME) in pancreatic cancer contributes to tumor progression in a multifaceted way.
- PAUF is called TME modulator which promotes cancer progression and metastasis via multiple pathways by stimulating cancer cell and stroma cell.
– Induces angiogenesis and vascular permeability
– Promotes cancer metastasis
– Causes suppressive tumor micro-environment (TME)
– Induces resistance to chemotherapeutics
![자산 15@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-15@3x-8-1.png)
![자산 1422@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-1422@3x-8.png)
- The tumor microenvironment (TME) in pancreatic cancer contributes to tumor progression in a multifaceted way.
- PAUF is called TME modulator which promotes cancer progression and metastasis via multiple pathways by stimulating cancer cell and stroma cell.
– Induces angiogenesis and vascular permeability
– Promotes cancer metastasis
– Causes suppressive tumor micro-environment (TME)
– Induces resistance to chemotherapeutics
![자산 19@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-19@3x-8.png)
Over-expressed in Pancreatic Cancer
![자산 20@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-20@3x-8.png)
- PAUF is over-expressed in over 80% of pancreatic adenocarcinoma.
- Reducing PAUF may improve survival of pancreatic cancer patients.
![자산 22@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-22@3x-8.png)
Over-expressed in Pancreatic Cancer
![자산 20@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-20@3x-8.png)
![자산 24@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-24@3x-8.png)
![자산 25@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-25@3x-8-1.png)
- PAUF is over-expressed in over 80% of pancreatic adenocarcinoma.
- Reducing PAUF may improve survival of pancreatic cancer patients.
![자산 23@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-23@3x-8.png)
![자산 18@3x-8](https://prestigebiopharma.com/wp-content/uploads/2023/10/자산-18@3x-8.png)
- Treatment
First-in-Class pancreatic cancer treatment to target PAUF
PBP1510 (INN:Ulenistamab)
Indication | Pancreatic Cancer, Ovarian Cancer |
Category | Monoclonal antibody |
Development Stage | Phase 1/2a (EU, USA & Asia) |
- PBP1510 specifically binds to PAUF and exerts anti-metastasis and immune modulation effects.
- PBP1510 demonstrates efficacy in Subcutaneous or Orthotopic Patient-derived Tumor Models
- Eligible patients with Advanced/MetastaticPancreatic Cancer will be effectively treated with PBP1510.
![presteigebiopharma_FDA_logo-8](https://prestigebiopharma.com/wp-content/uploads/2023/08/presteigebiopharma_FDA_logo-8-1.png)
- Diagnosis
PAUF detection in blood as pancreatic cancer screening
PAUF Detection Kit
Indication | Pancreatic Cancer |
Category | Diagnostic Kit |
Development Stage | Discovery |
- Carbohydrate antigen 19-9(CA19-9) is the only approved biomarker for pancreatic cancer so far, but it has low specificity.
- The novel diagnostic method exhibits high sensitivity and specificity in detecting PAUF.
- In our preliminary data, PAUF showed a superior diagnostic power that can overcome the weaknesses of current biomarker in pancreatic cancer.
- Research Papers related to PAUF
[1] PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway
[2] Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer
[3] A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis
[4] Pancreatic adenocarcinoma upregulated factor, a novel endothelial activator, promotes angiogenesis and vascular permeability
[5] Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma Oncogene (2011).
[6] Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation Cancer Sci (2009).